Innentitelbild: Access to N-Substituted 2-Pyridones by Catalytic Intermolecular Dearomatization and 1,4-Acyl Transfer (Angew. Chem. 7/2019)
نویسندگان
چکیده
منابع مشابه
Direct enantioselective access to 4-substituted tetrahydroquinolines by catalytic asymmetric transfer hydrogenation of quinolines.
A convenient protocol for the enantioselective synthesis of 4-substituted tetrahydroquinolines has been developed. Chiral BINOL phosphoric acids promote the reduction of a wide range of 4-substituted quinolines with Hantzsch esters with good to high levels of enantioselectivity.
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Novel intermediate oxazoline[3,2-a]pyridiniums were facilely prepared from 2-(2,2-dimethoxyethoxy)-pyridines via acid promoted intramolecular cyclization. Sequentially, the quaternary ammonium salts were treated with different nucleophiles for performing regioselective metal-free C-O and C-N bond-cleaving to afford prevalent heterocyclic structures of N-substituted pyridones and 2-substituted p...
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There are entries for the racemic alcohols 3 and 4, and also of enantiomerically pure 4. Our interest developed knowing the fact that pyrrolidine derivatives possess biological activities. For obtaining the aforementioned alcohols, our first approach was to prepare ketones 5a and 6 in the enantiomerically pure forms. In fact racemic 5 was prepared earlier in four steps by a tandem S N 2-Michael...
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In the course of experiments designed to elucidate the structure of reduced diphosphopyridine nucleotide (DPNH) (12), it became necessary to prepare the 2and 6-pyridones of iV-methylnicotinamidel by oxidation of the latter. Huff (5) has described the preparation of N’-methyl-6-pyridone-3-carboxylic acid by alkaline ferricyanide oxidation of either trigonelline or N’-methylnicotinamide. The acid...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2019
ISSN: 0044-8249
DOI: 10.1002/ange.201900202